![]() ![]() Of marrow stromal cells (40%, p=0.011) albeit at a lower rate. ![]() L14R8 significantly induced apoptosis in CLL samples (n = 4) cultured in suspensionĬultures (60%, p=0.023,) as well as CLL cells under microenvironmental protection ![]() ![]() L14R8 (10μM) induced apoptosisĪs early as 6 hrs along with mitochondrial outer membrane permeabilization (MOMP). The IC 50 of L14R8-induced apoptosis in CLL was 7.7μM (n=12, 24hrs). We have tested L14R8, a potent analogue of PAC, in primary CLL cells. Procaspase activating compounds (PAC Vanquish Oncology) convertĮxecutioner procaspases to their active forms by chelating labile zinc on these enzymes. Of procaspase-3, should overcome the checkpoints of cell death and trigger apoptosis Hence, we hypothesized that compounds that can directly activate the functional ability CLL cells have high threshold for inhibition of caspasesĪnd compared to normal counterparts, procaspase-3 is over-expressed in leukemia cells. Both intrinsic (caspase-9) and extrinsic (caspase-8) apoptosis pathways activateĭownstream procaspase-3. Of apoptosis proteins (IAPs) are primarily responsible for defective apoptosis inĬLL. High levels of Bcl-2 family anti-apoptotic and inhibitors Alternatively, follow me on social media – Facebook, Instagram and Twitter – for regular updates.Chronic lymphocytic leukemia (CLL) is a B cell malignancy and leukemia cells accumulateĭue to decreased apoptosis. If you would like to receive email notifications about my programmes, please fill this form. My writing programmes are three months long and are conducted twice a year – April to June, and October to December. I also run online book clubs and creative writing programmes for children and teenagers. As a rule, new editions of my book club for ages seven and eight, and Read, Write, Explore for ages nine and ten begin every alternate month. I went on to mice who turned into fairies and pixies who never drove or gave away their cars.Ī little older now, I have two collections of short stories , three middle-grade novels, two chapter books, four picture books, two series of books on trains, plus stories and essays here and there. I began my publishing “career” at the age of seven and a half with a story about a dame (blame Enid Blyton for that) who hated plants. I love writing for children, and have been writing since I was seven. ![]()
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